Longevity and Anti-Aging

SS-31 + Cardiogen

Mitochondrial & Cardiac Bioregulator

The SS-31 + Cardiogen Blend is a comprehensive cardiac longevity protocol that repairs the heart's mitochondrial energy infrastructure at the cellular level while simultaneously resetting cardiac gene expression to patterns seen in younger, healthier hearts. Together they address cardiac aging from two angles no conventional therapy reaches: the bioenergetic and the genomic.

Product

Ready-to-use pen
3 disposable micro needles

30 mgInjectableBlend

Research shows

Restores heart mitochondria
More youthful heart gene expression
Supports fitness and recovery
Less cardiac fibrosis and stiffness

View SS-31 + Cardiogen in our research library

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Mechanism

How SS-31 + Cardiogen Works

SS-31 binds to cardiolipin in the inner mitochondrial membrane of cardiomyocytes, restoring cristae architecture, reducing reactive oxygen species production, and improving ATP synthesis efficiency. Cardiogen (Ala-Glu-Asp-Leu) binds to cardiac cell DNA and activates gene expression patterns characteristic of healthy young cardiac tissue, normalising protein synthesis, improving cardiomyocyte contractility, and reducing fibrotic processes in the heart. The synergy produces improvements in cardiac output, exercise tolerance, and recovery from exertion at the cellular level.

Benefits

What SS-31 + Cardiogen Does

Based on published research and preclinical data. All benefits are documented under research-grade conditions.

Two Complementary Cardiac Protection Mechanisms

SS-31 and Cardiogen address cardiac health from opposite ends of the biological hierarchy: SS-31 repairs the mitochondrial energy infrastructure of cardiomyocytes, while Cardiogen works at the genomic level to normalise cardiac gene expression patterns: producing complementary protection that neither compound achieves alone.

SS-31: Cardiolipin & Mitochondrial Cristae Repair

SS-31 selectively concentrates in the inner mitochondrial membrane and stabilises cardiolipin: the phospholipid essential for cristae architecture and electron transport chain function. In cardiac tissue, which is among the highest mitochondrial-density tissue in the body, this restoration is of particular importance for sustained ATP output.

Cardiogen: Epigenetic Cardiac Reset

Cardiogen (Ala-Glu-Asp-Leu) is a tetrapeptide bioregulator that penetrates cardiomyocyte nuclei and interacts with DNA, activating gene expression patterns associated with young, healthy heart tissue. Clinical data from the Khavinson Institute documents improved cardiac contractility and reduced arrhythmia frequency.

Exercise Tolerance & Cardiac Output

The combined effect of improved mitochondrial ATP synthesis (SS-31) and normalised cardiac gene expression (Cardiogen) translates to improved cardiac output under exertion, reduced recovery time after physical stress, and better sustained cardiovascular performance.

Post-Cardiac Injury Recovery

Both components have demonstrated cardiac protective effects in ischaemia-reperfusion models. SS-31 reduces cardiomyocyte apoptosis after ischaemic injury while Cardiogen promotes the restoration of normal contractile protein expression. Together they support recovery of cardiac function after injury.

Longevity-Oriented Cardiac Support

Cardiovascular disease remains the leading cause of age-related mortality globally. This blend addresses mitochondrial and genomic aspects of cardiac aging that are not targeted by conventional cardiology interventions: making it a uniquely proactive component of a longevity protocol.

Research

Research on SS-31 + Cardiogen

Explore selected publications and registered trials on SS-31 + Cardiogen, with links to the original sources.

In mice, elamipretide reduced mitochondrial dysfunction, oxidative stress and neuroinflammation while improving synaptic structure, learning and memory after lipopolysaccharide exposure.

Journal of neuroinflammation

Source

View publication on PubMed

PMID 31747905 · 2019

Registered clinical trials

5 selected studies from the wider trial library, in the order chosen for this product.

CompletedPhase 2 / Phase 3Results posted

A Trial to Evaluate Safety, Tolerability and Efficacy of Elamipretide in Subjects With Barth Syndrome

12 participants registeredStealth BioTherapeutics Inc.

View trial on ClinicalTrials.gov

NCT03098797

CompletedPhase 2Results posted

Evaluation of Myocardial Effects of MTP-131 for Reducing Reperfusion Injury in Patients With Acute Coronary Events

300 participants registeredStealth BioTherapeutics Inc.

View trial on ClinicalTrials.gov

NCT01572909

CompletedPhase 2Results posted

ReCLAIM-2 Study to Evaluate Safety,Efficacy & Pharmacokinetics of Elamipretide in Subjects With AMD With Non-central GA

176 participants registeredStealth BioTherapeutics Inc.

View trial on ClinicalTrials.gov

NCT03891875

CompletedPhase 2Results posted

Effect of Elamipretide on Left Ventricular Function in Subjects With Stable Heart Failure With Reduced Ejection Fraction

71 participants registeredStealth BioTherapeutics Inc.

View trial on ClinicalTrials.gov

NCT02788747

CompletedPhase 2Results posted

A Phase 2 Study to Evaluate the Impact of MTP-131 (Bendaviaâ¢) on Skeletal Muscle Function in Elderly

41 participants registeredStealth BioTherapeutics Inc.

View trial on ClinicalTrials.gov

NCT02245620

Explore the Labbieux research libraryView all SS-31 + Cardiogen records or browse research across all our productsOpen library

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SS-31 + Cardiogen

Product facts

How SS-31 + Cardiogen Works

What SS-31 + Cardiogen Does

Two Complementary Cardiac Protection Mechanisms

SS-31: Cardiolipin & Mitochondrial Cristae Repair

Cardiogen: Epigenetic Cardiac Reset

Exercise Tolerance & Cardiac Output

Post-Cardiac Injury Recovery

Longevity-Oriented Cardiac Support

Research on SS-31 + Cardiogen

Published research

Long-term efficacy and safety of elamipretide in patients with Barth syndrome: 168-week open-label extension results of TAZPOWER.

[The effect of the amino acids and cardiogen on the development of myocard tissue culture from young and old rats].

Efficacy and Safety of Elamipretide in Individuals With Primary Mitochondrial Myopathy: The MMPOWER-3 Randomized Clinical Trial.

Tumor-modifying effect of cardiogen peptide on M-1 sarcoma in senescent rats.

Elamipretide (SS-31) improves mitochondrial dysfunction, synaptic and memory impairment induced by lipopolysaccharide in mice.

Registered clinical trials

A Trial to Evaluate Safety, Tolerability and Efficacy of Elamipretide in Subjects With Barth Syndrome

Evaluation of Myocardial Effects of MTP-131 for Reducing Reperfusion Injury in Patients With Acute Coronary Events

ReCLAIM-2 Study to Evaluate Safety,Efficacy & Pharmacokinetics of Elamipretide in Subjects With AMD With Non-central GA

Effect of Elamipretide on Left Ventricular Function in Subjects With Stable Heart Failure With Reduced Ejection Fraction

A Phase 2 Study to Evaluate the Impact of MTP-131 (Bendaviaâ¢) on Skeletal Muscle Function in Elderly

Protocol

Using the pen

Side Effects & Tolerability

Certificates of Analysis

SS-31

Cardiogen

More from Longevity and Anti-Aging

Epitalon

Humanin

NAD 300+

Epitalon

Humanin

NAD 300+

SS-31 + Cardiogen

Product facts

How SS-31 + Cardiogen Works

What SS-31 + Cardiogen Does

Two Complementary Cardiac Protection Mechanisms

SS-31: Cardiolipin & Mitochondrial Cristae Repair

Cardiogen: Epigenetic Cardiac Reset

Exercise Tolerance & Cardiac Output

Post-Cardiac Injury Recovery

Longevity-Oriented Cardiac Support

Research on SS-31 + Cardiogen

Published research

Long-term efficacy and safety of elamipretide in patients with Barth syndrome: 168-week open-label extension results of TAZPOWER.

[The effect of the amino acids and cardiogen on the development of myocard tissue culture from young and old rats].

Efficacy and Safety of Elamipretide in Individuals With Primary Mitochondrial Myopathy: The MMPOWER-3 Randomized Clinical Trial.

Tumor-modifying effect of cardiogen peptide on M-1 sarcoma in senescent rats.

Elamipretide (SS-31) improves mitochondrial dysfunction, synaptic and memory impairment induced by lipopolysaccharide in mice.

Registered clinical trials

A Trial to Evaluate Safety, Tolerability and Efficacy of Elamipretide in Subjects With Barth Syndrome

Evaluation of Myocardial Effects of MTP-131 for Reducing Reperfusion Injury in Patients With Acute Coronary Events

ReCLAIM-2 Study to Evaluate Safety,Efficacy & Pharmacokinetics of Elamipretide in Subjects With AMD With Non-central GA

Effect of Elamipretide on Left Ventricular Function in Subjects With Stable Heart Failure With Reduced Ejection Fraction

A Phase 2 Study to Evaluate the Impact of MTP-131 (Bendaviaâ¢) on Skeletal Muscle Function in Elderly

Protocol

Using the pen

Side Effects & Tolerability

Certificates of Analysis

SS-31

Cardiogen

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Epitalon

Humanin

NAD 300+

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A Phase 2 Study to Evaluate the Impact of MTP-131 (Bendaviaâ¢) on Skeletal Muscle Function in Elderly