Epithalamin Peptide
Epitalon is a pineal peptide that activates telomerase, the enzyme responsible for protecting and extending telomeres: the molecular caps that determine how fast your cells age. It restores melatonin production, normalises hormonal rhythms, and is one of the most studied longevity compounds available.
Product
Research shows
Practical product identifiers and format details for professional review.
Content
30 mg
Format
Injectable
Composition
10 mg/ml per ml
Epitalon stimulates telomerase activity: the enzyme responsible for elongating telomeres, the protective nucleoprotein caps at the ends of chromosomes. Telomere shortening occurs with every cell division and is a primary molecular marker of biological aging; telomerase activation slows this erosion and has been associated with extended cellular lifespan in multiple studies. Epitalon also stimulates the pineal gland to restore melatonin synthesis to levels consistent with younger biological age, normalises hypothalamic-pituitary-adrenal axis function, and reduces lipid peroxidation through its antioxidant properties.
Based on published research and preclinical data. All benefits are documented under research-grade conditions.
Epitalon is one of the few compounds demonstrated to activate telomerase (the enzyme that elongates telomeres) in human somatic cells. Telomere shortening is a primary molecular marker of biological aging; Epitalon's ability to slow this erosion is the cornerstone of its anti-aging profile.
The pineal gland produces melatonin in declining amounts with age. Epitalon restores pineal function and normalises melatonin synthesis, improving circadian rhythm entrainment, sleep architecture, and the downstream antioxidant functions that melatonin regulates.
Long-term studies reported maximum-lifespan extensions of 25 to 33% versus untreated controls, alongside research into age-related tumour incidence, immune function, and the pace of neuroendocrine decline.
Epitalon reduces lipid peroxidation products and normalises antioxidant enzyme activity in aging tissues. This protective effect on DNA integrity is consistent with its role in reducing age-associated chromosomal instability and oncogenesis.
By resetting hypothalamic-pituitary axis function, Epitalon normalises hormonal signalling that drifts with age (including cortisol rhythms, thyroid function, and gonadotropin levels) toward a younger biological baseline.
Clinical and preclinical data from Professor Khavinson's group documents Epitalon's ability to restore thymic function and T-cell immunity in elderly subjects. This immune restoration is a critical component of its longevity profile.
Explore selected publications on Epitalon, with links to the original sources.
5 publications from the research library.
Evidence type
Publication and key finding
Source
Evidence type
Review
Direct or closely related Epitalon evidence
Publication and key finding
A technology has been developed for manufacturing of biologically active complex peptide preparations from extracts of different tissues.
Neuro endocrinology letters
Evidence type
Observational study
Epitalon mechanism or target context
Publication and key finding
The polypeptide complex of the epiphysis and the peptide AEDG, constructed on the basis of its amino acid analysis, exert similar biological effects.
Bulletin of experimental biology and medicine
Evidence type
Review
Direct or closely related Epitalon evidence
Publication and key finding
Epitalon, also known as Epithalon or Epithalone, is a tetrapeptide, Ala-Glu-Asp-Gly (AEDG), which was synthesized based on the amino acids composition of Epithalamin, a bovine pineal gland extract, prior to its discovery in pineal gland polypeptide complex solution.
International journal of molecular sciences
Evidence type
Laboratory study
Direct or closely related Epitalon evidence
Publication and key finding
Addition of Epithalon peptide in telomerase-negative human fetal fibroblast culture induced expression of the catalytical subunit, enzymatic activity of telomerase, and telomere elongation, which can be due to reactivation of telomerase gene in somatic cells and indicates the possibility of prolonging life span of a cell population and.
Bulletin of experimental biology and medicine
Evidence type
Observational study
Direct or closely related Epitalon evidence
Publication and key finding
We previously showed that treatment of normal human diploid cells with Epithalon (Ala-Glu-Asp-Gly) induced expression of telomerase catalytic subunit, its enzymatic activity, and elongation of telomeres.
Bulletin of experimental biology and medicine
Labbieux pens are designed for 30 to 31 administrations of 10 clicks. With daily use, this corresponds to approximately one month. We recommend starting with 5 clicks and building up to 10 clicks per administration. More sensitive people may use fewer clicks.
Before using our pens, consult the manual.
Epitalon has been used in clinical research for over 40 years across thousands of subjects with a generally favourable safety record. It is a naturally derived tetrapeptide with no known significant adverse effects at standard research doses. Injection-site discomfort such as minor redness or swelling has occasionally been reported. Unlike many longevity interventions, Epitalon does not appear to stimulate growth-factor pathways that could theoretically accelerate latent tumour growth; preclinical research has instead examined reduced tumour incidence. No hormonal disruption, hepatotoxicity, or renal effects have been reported. Given its short cycle structure (10–20 days on, months off), cumulative exposure is inherently limited.
This public COA documents one selected production batch and is updated annually. It is not the COA for our latest available batch. Every batch has its own documentation, and partners can request the latest batch COA from our team.
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