Humanin

Evidence type

Observational study

Direct or closely related Humanin evidence

Publication and key finding

Mechanisms of neuroprotection by a novel rescue factor humanin from Swedish mutant amyloid precursor protein.

We report a novel gene, designated Humanin (HN) cDNA, that suppresses neuronal cell death by K595N/M596L-APP (NL-APP), a mutant causing familial Alzheimer's disease (FAD), termed Swedish mutant.

Biochemical and biophysical research communications

Source

PMID 11327724 · 2001

Evidence type

Published research

Humanin mechanism or target context

Publication and key finding

The role of mitochondrial derived peptides (MDPs) in metabolism.

This publication examines the role of mitochondrial derived peptides (mdps) in metabolism.

Journal of cellular physiology

Source

PMID 25893266 · 2015

Evidence type

Laboratory study

Direct or closely related Humanin evidence

Publication and key finding

Naturally occurring mitochondrial-derived peptides are age-dependent regulators of apoptosis, insulin sensitivity, and inflammatory markers.

Mitochondria are key players in aging and in the pathogenesis of age-related diseases.

Aging

Source

PMID 27070352 · 2016

Evidence type

Preclinical study

Direct or closely related Humanin evidence

Publication and key finding

Humanin, a newly identified neuroprotective factor, uses the G protein-coupled formylpeptide receptor-like-1 as a functional receptor.

Alzheimer's disease (AD) is characterized by overproduction of beta amyloid peptides in the brain with progressive loss of neuronal cells.

Journal of immunology (Baltimore, Md. : 1950)

Source

PMID 15153530 · 2004