Intranasal Cognitive Stack
AC-Selank + AC-Semax Spray combines the peptides AC-Selank-NH2 and AC-Semax-NH2 in a nasal spray, for non-injectable protocols.
Research shows
Practical product identifiers and format details for professional review.
Content
100 mg
Format
Nasal Spray
Composition
5 mg/ml + 5 mg/ml per ml
Intranasal administration delivers both peptides to the olfactory epithelium, from where they travel along olfactory nerves directly into the cerebrospinal fluid and brain tissue within minutes: significantly faster and more direct than subcutaneous injection for CNS targets. AC-Selank modulates GABAergic and serotonergic tone to reduce anxiety and background cognitive noise, creating a calm attentional baseline. AC-Semax simultaneously elevates BDNF and dopaminergic signalling in the prefrontal cortex, sharpening executive function, working memory, and processing speed. The result is the experience of high-clarity, high-focus cognitive performance without the anxious edge.
Based on published research and preclinical data. All benefits are documented under research-grade conditions.
Intranasal administration allows peptides to travel along olfactory nerve fibres directly into the cerebrospinal fluid and brain tissue: bypassing the blood-brain barrier and first-pass metabolism. Effects begin within minutes rather than the 20-40 minutes typical of subcutaneous injection, making this format uniquely suited for acute cognitive performance support.
AC-Semax-NH2 alone can produce focused, driven cognitive states that may amplify stress in high-pressure environments. AC-Selank-NH2 simultaneously modulates GABAergic tone and cortisol output, creating a calm attentional baseline that allows focus to express without the anxious edge. The two peptides produce a qualitatively different cognitive state than either alone.
AC-Semax's BDNF-driven enhancement of prefrontal dopaminergic transmission directly improves working memory capacity, processing speed, and executive function. These effects are measurable in psychometric testing and translate into practical performance improvements in cognitively demanding tasks.
As an intranasal spray, this format requires no reconstitution, no needle, and no injection preparation. It fits seamlessly into morning routines and can be used in any environment: making daily cognitive support accessible without the logistical and psychological friction of injectable administration.
AC-Selank addresses the anxiety and stress dimensions of cognitive performance (reducing noise), while AC-Semax addresses the output dimensions (increasing signal). By operating on two distinct but complementary neurochemical pathways simultaneously, the combination produces a degree of cognitive clarity that neither peptide achieves individually.
Neither component produces the receptor downregulation, tolerance build-up, or stimulant-style rebound that limits the utility of conventional nootropics. Both peptides support their cognitive effects via neurotrophic and neuroplasticity mechanisms that benefit from consistent use, making this spray a genuinely sustainable daily cognitive tool.
Explore selected publications on AC-Selank + AC-Semax Spray, with links to the original sources.
5 publications from the research library.
Evidence type
Publication and key finding
Source
Evidence type
Observational study
Direct or closely related Semax evidence
Publication and key finding
This publication examines [effect of the heptapeptide semax on the human electroencephalogram].
Biulleten' eksperimental'noi biologii i meditsiny
Evidence type
Preclinical study
Direct or closely related Selank evidence
Publication and key finding
Thus, we hypothesized and showed that one of Selank anti-anxiety molecular mechanisms can be associated with subtype selective concentration - dependent allosteric modulation of GABA receptors.
Protein and peptide letters
Evidence type
Preclinical study
Direct or closely related Semax evidence
Publication and key finding
Heptapeptide Semax (MEHFPGP) is the fragment of ACTH(4-10) analogue with prolonged neurotropic activity.
Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova
Evidence type
Preclinical study
Direct or closely related Selank evidence
Publication and key finding
Clinical studies have shown the similarity of the spectrum of physiological effects of Selank and classical benzodiazepines, such as diazepam and phenazepam.
Frontiers in pharmacology
Evidence type
Preclinical study
Direct or closely related Semax evidence
Publication and key finding
The heptapeptide Semax (Met-Glu-His-Phe-Pro-Gly-Pro) is an analog of the adrenocorticotropin fragment (4-10) which after intranasal application has profound effects on learning and exerts marked neuroprotective activities.
Brain research
The intranasal spray format is very well tolerated. Mild transient nasal mucosal irritation is the most commonly noted observation from intranasal peptide use, typically resolving within minutes. No systemic adverse effects, no tolerance formation, and no withdrawal effects have been documented for either AC-Selank-NH2 or AC-Semax-NH2. No cardiovascular, hepatic, renal, or hormonal toxicity has been associated with either peptide in research settings. The non-systemic delivery route further reduces the risk of any peripheral side effects.
This formulation combines AC-Selank-NH2 and AC-Semax-NH2. The individual public COA for each component is listed below.
Each public COA documents one selected production batch and is updated annually. It is not the COA for our latest available batch. Every batch has its own documentation, and partners can request the latest batch COAs from our team.
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