Research library

Key finding

In mice, MOTS-c activated AMPK-linked metabolic signalling and prevented age-related and high-fat-diet-induced insulin resistance and obesity.

Key finding

This receptor review maps VIP and PACAP signalling across immune, metabolic, cardiovascular and neural systems through VPAC1, VPAC2 and PAC1 receptors.

Key finding

MOTS-c increased after exercise in people and restored physical capacity and skeletal-muscle homeostasis in aged mice.

Key finding

This review describes how VIP signalling regulates T cells and macrophages and can shift inflammatory responses toward immune-regulatory activity.

Key finding

In healthy ageing men, skeletal-muscle MOTS-c expression was associated with muscle-fibre composition, linking this mitochondrial peptide to human muscle biology.

Key finding

The study reports that different tissues co-expressed the protein with mitochondria, and plasma also contained the protein, but its level decreased with age.

Key finding

The study reports that vasoactive intestinal peptide (VIP) is an abundant neurotransmitter in the lungs and other organs.

Key finding

The study reports that genetic ablation of this peptide and its receptors in mice also provides new insights into the contribution of VIP towards physiological signaling and the pathogenesis of related diseases.

Key finding

Primary pulmonary hypertension is a fatal disease causing progressive right heart failure within 3 years after diagnosis.

Key finding

Skeletal muscle adapts to aerobic exercise training, in part, through fast-to-slow phenotypic shifts and an expansion of mitochondrial networks.

Key finding

Obesity and type 2 diabetes are metabolic diseases, often associated with sarcopenia and muscle dysfunction.

Key finding

MOTS-c is an exercise mimetic and improves insulin sensitivity in aged and diet-induced obese mice.

Key finding

MOTS-c promotes cell differentiation of BMSCs to osteoblasts via TGF-β/Smad pathway.

Key finding

Therapeutic targeting bone loss has been the focus of the study in osteoporosis.

Key finding

Vasoactive intestinal peptide (VIP) and pituitary adenylyl cyclase-activating polypeptide (PACAP) are two structurally-related neuropeptides with widespread expression in the central and peripheral nervous systems.

Key finding

We show that vasoactive intestinal peptide (VIP) exerts trophic and proangiogenic activities in experimental prostate cancer in vivo.

Key finding

Cellular homeostasis is coordinated through communication between mitochondria and the nucleus, organelles that each possess their own genomes.

Key finding

Mitochondrial-derived peptides (MDPs) are encoded by the mitochondrial genome and hypothesised to form part of a retrograde signalling network that modulates adaptive responses to metabolic stress.

Key finding

Pulmonary hypertension (PH) leads to an increased right ventricular workload, cardiac failure and death.

Key finding

The identification of regulatory T (Treg) cells as important regulators of self-tolerance has opened up new therapeutic avenues for the treatment of several human diseases associated with Treg dysfunction, including autoimmune diseases and transplantation.