Research library

Key finding

In full-thickness rat wounds, full-length thymosin beta-4 increased re-epithelialization by up to 61%, collagen deposition and angiogenesis.

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Thymosin beta-4 and a synthetic actin-binding-domain fragment accelerated dermal repair in diabetic and aged mice.

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This review links thymosin beta-4 to cell migration, angiogenesis, reduced inflammation and repair across dermal, corneal and cardiac injury models.

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This translational review summarizes thymosin beta-4's roles in cell migration, blood-vessel formation, inflammation control and tissue regeneration.

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The review consolidates evidence that thymosin beta-4 supports cytoprotection, angiogenesis and tissue repair through actin regulation.

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The study reports that the present study reveals the progress regarding functions and applications of Tβ4.

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The objective of this double-blind, placebo-controlled, dose-escalation study is to evaluate safety, tolerability, and enhancement on healing of thymosin beta-4 (Tbeta-4) administered topically in patients with venous ulcers.

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This publication examines treatment of chronic nonhealing neurotrophic corneal epithelial defects with thymosin beta 4.

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Thymosin beta 4 (T beta 4) is a 4.9 kDa polypeptide that interacts with G-actin and is thought to be an important mediator in cell proliferation, migration, and differentiation.

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These findings underscore the crucial role of rhTB4 in mitigating cardiac dysfunction in an ErbB2-dependent manner.

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Chronic nonhealing cutaneous wounds are a worldwide problem with no agent able to promote healing.

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Previously, thymosin beta 4 (Tbeta(4)) was found to promote wound healing in full thickness skin wounds and heptanol debrided corneas.

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Synthetic thymosin beta 4 (Tbeta4) may have a potential use in promoting myocardial cell survival during acute myocardial infarction.

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The formulation TB-500 is suspected to be used as doping agent in sport.

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At least 50% of the actin in resting human platelets is unpolymerized, and the bulk of this unpolymerized actin is complexed with a recently identified acidic, heat-stable 5-kDa peptide, named "Fx." Purified Fx binds stoichiometrically to muscle G-actin, forming a complex identifiable by nondenaturing polyacrylamide gel electrophoresis.

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Thymosin beta-4 (Tβ4) is known to induce hair growth and hair follicle (HF) development; however, its mechanism of action is unknown.

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A veterinary preparation known as TB-500 and containing a synthetic version of the naturally occurring peptide LKKTETQ has emerged.

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Our dream of defeating the processes of organ damage and aging remains a challenge scientists pursued for hundreds of years.

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Thymosin beta 4 (Tβ4) has important applications in ocular repair and Phase 3 clinical trials using Tβ4 to treat dry eye and neurotrophic keratopathy are currently ongoing.

Key finding

Chronic ocular surface diseases such as dry eye, blepharitis, and neurotrophic keratopathies represent a significant and a growing therapeutic challenge.