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Research library

Explore selected publications, evidence types, key findings, and registered studies with direct links to each primary record. This curated library is not a complete archive of the thousands of studies across the wider scientific literature.

PublicationsClinical trials

5 publications

Showing records relevant to SS-31.

Human randomized

Long-term efficacy and safety of elamipretide in patients with Barth syndrome: 168-week open-label extension results of TAZPOWER.

Key finding

The study reports that mean BTHS-SA Total Fatigue scores were below baseline (improved) at all OLE time points.

Genetics in medicine : official journal of the American College of Medical Genetics 2024

Research relevant to SS-31. Relevant to SS-31

PubMed
Human randomized

Efficacy and Safety of Elamipretide in Individuals With Primary Mitochondrial Myopathy: The MMPOWER-3 Randomized Clinical Trial.

Key finding

The study reports that at baseline, the mean distance walked on the 6MWT was 336.7 ± 81.2 meters, the mean score for total fatigue on the PMMSA was 10.6 ± 2.5, and the mean T score for the Neuro-QoL Fatigue Short-Form was 54.7 ± 7.5.

Neurology 2023

Research relevant to SS-31. Relevant to SS-31

PubMed
Preclinical animal

Elamipretide (SS-31) improves mitochondrial dysfunction, synaptic and memory impairment induced by lipopolysaccharide in mice.

Key finding

The study reports that lPS-induced memory impairment can be attenuated by the mitochondrion-targeted antioxidant elamipretide.

Journal of neuroinflammation 2019

Direct SS-31 evidence. Relevant to SS-31

PubMed
Review

Elamipretide: A Review of Its Structure, Mechanism of Action, and Therapeutic Potential.

Key finding

The study reports that further research may expand its application to other diseases involving mitochondrial dysfunction as well as investigate long-term efficacy and safety of the drug.

International journal of molecular sciences 2025

Research relevant to SS-31. Relevant to SS-31

PubMed
Review

Serendipity and the discovery of novel compounds that restore mitochondrial plasticity.

Key finding

The study reports that this mitochondrial plasticity is reduced in many age-associated diseases.

Clinical pharmacology and therapeutics 2014

Research relevant to SS-31. Relevant to SS-31

PubMed

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