Research library
Explore selected publications, evidence types, key findings, and registered studies with direct links to each primary record. This curated library is not a complete archive of the thousands of studies across the wider scientific literature.
28 publications
Showing records relevant to Epitalon.
Identification of Peptide AEDG in the Polypeptide Complex of the Pineal Gland.
Key finding
The polypeptide complex of the epiphysis and the peptide AEDG, constructed on the basis of its amino acid analysis, exert similar biological effects.
Bulletin of experimental biology and medicine 2017
Epitalon mechanism or target context. Relevant to Epitalon
Overview of Epitalon-Highly Bioactive Pineal Tetrapeptide with Promising Properties.
Key finding
Epitalon, also known as Epithalon or Epithalone, is a tetrapeptide, Ala-Glu-Asp-Gly (AEDG), which was synthesized based on the amino acids composition of Epithalamin, a bovine pineal gland extract, prior to its discovery in pineal gland polypeptide complex solution.
International journal of molecular sciences 2025
Direct or closely related Epitalon evidence. Relevant to Epitalon
Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells.
Key finding
Addition of Epithalon peptide in telomerase-negative human fetal fibroblast culture induced expression of the catalytical subunit, enzymatic activity of telomerase, and telomere elongation, which can be due to reactivation of telomerase gene in somatic cells and indicates the possibility of prolonging life span of a cell population and.
Bulletin of experimental biology and medicine 2003
Direct or closely related Epitalon evidence. Relevant to Epitalon
Peptide promotes overcoming of the division limit in human somatic cell.
Key finding
We previously showed that treatment of normal human diploid cells with Epithalon (Ala-Glu-Asp-Gly) induced expression of telomerase catalytic subunit, its enzymatic activity, and elongation of telomeres.
Bulletin of experimental biology and medicine 2004
Direct or closely related Epitalon evidence. Relevant to Epitalon
Antioxidant properties of geroprotective peptides of the pineal gland.
Key finding
The study reports that the possibility of oxidation chains by their interaction with different ROS by means of binding of transition metals (Fe(2+)) cannot also be excluded.
Archives of gerontology and geriatrics 2007
Research relevant to Epitalon. Relevant to Epitalon
Peptide geroprotector from the pituitary gland inhibits rapid aging of elderly people: results of 15-year follow-up.
Key finding
The paper presents the results of randomized comparative study of the efficiency of peptide geroprotector from the pituitary gland in elderly patients with rapidly aging cardiovascular system.
Bulletin of experimental biology and medicine 2011
Direct or closely related Epitalon evidence. Relevant to Epitalon
Geroprotective effect of epithalamine (pineal gland peptide preparation) in elderly subjects with accelerated aging.
Key finding
A 12-year randomized clinical study of epithalamine (pineal gland peptide preparation) was carried out in elderly patients with coronary disease and accelerated aging of the cardiovascular system.
Bulletin of experimental biology and medicine 2006
Direct or closely related Epitalon evidence. Relevant to Epitalon
Pineal-regulating tetrapeptide epitalon improves eye retina condition in retinitis pigmentosa.
Key finding
The study reports that epitalon therapy in patients with degenerative retinal lesions results in a positive clinical effect in 90% of the cases.
Neuro endocrinology letters 2002
Direct Epitalon evidence. Relevant to Epitalon
The Antioxidant Tetrapeptide Epitalon Enhances Delayed Wound Healing in an in Vitro Model of Diabetic Retinopathy.
Key finding
Diabetic retinopathy (DR) is the most common complication of diabetes mellitus and a leading cause of vision loss.
Stem cell reviews and reports 2025
Direct or closely related Epitalon evidence. Relevant to Epitalon
Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity.
Key finding
Epitalon, a naturally occurring tetrapeptide, is known for its anti-aging effects on mammalian cells.
Biogerontology 2025
Direct or closely related Epitalon evidence. Relevant to Epitalon
Epitalon-activated telomerase enhance bovine oocyte maturation rate and post-thawed embryo development.
Key finding
Telomerase is highly expressed in oocyte cumulus cells and plays a significant role in follicular development and oocyte maturation.
Life sciences 2025
Direct or closely related Epitalon evidence. Relevant to Epitalon
[Effect of epitalon and melatonin on life span and spontaneous carcinogenesis in senescence accelerated mice (SAM)].
Key finding
Female senescence accelerated mice SAMP-1. (prone) and SAMR-1 (resistant) were exposed 5 times a week monthly to melatonin (with drinking water 20mg/ml during the night hours) or to s.c. injections of epitalon (Ala-Glu-Asp-Gly) at a single dose 1mkg/mouse.
Voprosy onkologii 2005
Direct or closely related Epitalon evidence. Relevant to Epitalon
AEDG Peptide (Epitalon) Stimulates Gene Expression and Protein Synthesis during Neurogenesis: Possible Epigenetic Mechanism.
Key finding
The study reports that aEDG peptide increased Nestin, GAP43, β Tubulin III and Doublecortin mRNA expression by 1.6-1.8 times in hGMSCs.
Molecules (Basel, Switzerland) 2020
Direct Epitalon evidence. Relevant to Epitalon
Peptides of pineal gland and thymus prolong human life.
Key finding
The obtained data confirmed the high geroprotective efficacy of Thymalin and Epithalamin and the expediency of their application in medicine and social care for health maintenance and age-related pathology prevention in persons over 60 to prolong their active longevity.
Neuro endocrinology letters 2003
Direct or closely related Epitalon evidence. Relevant to Epitalon
Peptides Regulating Proliferative Activity and Inflammatory Pathways in the Monocyte/Macrophage THP-1 Cell Line.
Key finding
These peptides (Khavinson Peptides®), characterized by Prof.
International journal of molecular sciences 2022
Direct or closely related Epitalon evidence. Relevant to Epitalon
Geroprotective effect of ala-glu-asp-gly peptide in male rats exposed to different illumination regimens.
Key finding
Exposure of male rats to permanent or natural illumination of North-Western Russia accelerated their death in comparison with animals exposed to standard (12 h) light.
Bulletin of experimental biology and medicine 2008
Direct or closely related Epitalon evidence. Relevant to Epitalon
Effect of Ala-Glu-Asp-Gly peptide on life span and development of spontaneous tumors in female rats exposed to different illumination regimes.
Key finding
The effects of Ala-Glu-Asp-Gly peptide (Epithalon) on the life span and development of spontaneous tumors were studied in female rats exposed to standard, natural for North-Western Russia, and constant illumination.
Bulletin of experimental biology and medicine 2007
Direct or closely related Epitalon evidence. Relevant to Epitalon
Effect of the synthetic pineal peptide epitalon on spontaneous carcinogenesis in female C3H/He mice.
Key finding
The potential preventive effect of the synthetic pineal peptide Epitalon (Ala-Glu-Asp-Gly) on spontaneous tumorigenesis in mice was studied.
In vivo (Athens, Greece) 2006
Direct or closely related Epitalon evidence. Relevant to Epitalon
The role of pineal gland in breast cancer development.
Key finding
The role of the modulation of the pineal gland function in development of breast cancer is discussed in this review.
Critical reviews in oncology/hematology 2003
Direct or closely related Epitalon evidence. Relevant to Epitalon
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