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Research library

Explore selected publications, evidence types, key findings, and registered studies with direct links to each primary record. This curated library is not a complete archive of the thousands of studies across the wider scientific literature.

PublicationsClinical trials

21 publications

Showing records relevant to Delta Sleep.

Preclinical animal

Pichia pastoris secreted peptides crossing the blood-brain barrier and DSIP fusion peptide efficacy in PCPA-induced insomnia mouse models.

Key finding

The study reports that the study underscores DSIP-CBBBP potential in correcting neurotransmitter dysregulation and promoting sleep, hinting at its utility in sleep-related therapies.

Frontiers in pharmacology 2024

Research relevant to Delta Sleep. Relevant to Delta Sleep

PubMed
Human randomized

Effects of delta sleep-inducing peptide on sleep of chronic insomniac patients. A double-blind study.

Key finding

The study reports that one measure of subjectively estimated tiredness decreased within the DSIP group.

Neuropsychobiology 1992

Direct Delta Sleep evidence. Relevant to Delta Sleep

PubMed
Review

Delta-sleep-inducing peptide (DSIP): a review.

Key finding

The study reports that since the turn of the century, it has been postulated that humoral factors induce sleep.

Neuroscience and biobehavioral reviews 1984

Direct Delta Sleep evidence. Relevant to Delta Sleep

PubMed
Human clinical

Opioid detoxification with delta sleep-inducing peptide: results of an open clinical trial.

Key finding

This publication reports research findings relevant to opioid detoxification with delta sleep-inducing peptide: results of an open clinical trial.

Journal of clinical psychopharmacology 1998

Direct Delta Sleep evidence. Relevant to Delta Sleep

PubMed
Human clinical

Study of delta sleep-inducing peptide efficacy in improving sleep on short-term administration to chronic insomniacs.

Key finding

The study reports that the number of nocturnal awakenings, non-rapid-eye-movement (NREM) sleep latency, total waking time and waking time after sleep onset were decreased under DSIP treatment, but no significant differences were found in comparison to baseline or to double-blind placebo nights.

International journal of clinical pharmacology research 1987

Direct Delta Sleep evidence. Relevant to Delta Sleep

PubMed
Human randomized

Synthetic delta-sleep-inducing peptide improves sleep in insomniacs.

Key finding

This publication reports research findings relevant to synthetic delta-sleep-inducing peptide improves sleep in insomniacs.

Lancet (London, England) 1981

Direct Delta Sleep evidence. Relevant to Delta Sleep

PubMed
Human randomized

Reduction of immunoreactive ACTH in plasma following intravenous injection of delta sleep-inducing peptide in man.

Key finding

The study reports that a significant reduction of ACTH-like immunoreactivity (ACTH-LI) in plasma was detected for at least 3 hr after the DSIP injection, compared to the control subjects, in whom a slightly elevated concentration of ACTH-LI occurred.

Psychoneuroendocrinology 1989

Direct Delta Sleep evidence. Relevant to Delta Sleep

PubMed
Human randomized

Delta sleep-inducing peptide alters bispectral index, the electroencephalogram and heart rate variability when used as an adjunct to isoflurane anaesthesia.

Key finding

The study reports that dSIP significantly increased heart rate, decreased HRV and, paradoxically, significantly reduced delta rhythm along with reducing burst suppression and increasing BIS at 25 nmol kg(-1) during isoflurane anaesthesia.

European journal of anaesthesiology 2009

Direct Delta Sleep evidence. Relevant to Delta Sleep

PubMed
Human randomized

Different effects of delta-sleep-inducing peptide on arginine-vasopressin and ACTH secretion in normal men.

Key finding

The study reports that osmotic stimulation of AVP secretion by hypertonic NaCl induced a significant increase in plasma AVP concentrations which was not modified by DSIP administration.

Hormone research 1994

Direct Delta Sleep evidence. Relevant to Delta Sleep

PubMed
Human clinical

Delta-sleep-inducing peptide does not affect CRH and meal-induced ACTH and cortisol secretion.

Key finding

The study reports that meal-related midday surge of ACTH and cortisol was also not affected by DSIP.

Psychoneuroendocrinology 1995

Direct Delta Sleep evidence. Relevant to Delta Sleep

PubMed
Human clinical

Delta sleep-inducing peptide administration does not influence growth hormone and prolactin secretion in normal women.

Key finding

The study reports that the GH and PRL circadian rhythm was not modified by DSIP administration.

Psychoneuroendocrinology 1993

Direct Delta Sleep evidence. Relevant to Delta Sleep

PubMed
Human clinical

Effects of delta-sleep-inducing peptide on 24-hour sleep-wake behaviour in severe chronic insomnia.

Key finding

The study reports that alertness and performance at daytime increased significantly.

European neurology 1987

Direct Delta Sleep evidence. Relevant to Delta Sleep

PubMed
Human clinical

Acute and delayed effects of DSIP (delta sleep-inducing peptide) on human sleep behavior.

Key finding

The study reports that the subjects immediately reported a feeling of sleep pressure, and sleep increased by 59% (median of total sleep time) within a 130-min interval after the treatment as compared with placebo.

International journal of clinical pharmacology, therapy, and toxicology 1981

Direct Delta Sleep evidence. Relevant to Delta Sleep

PubMed
Human clinical

The influence of synthetic DSIP (delta-sleep-inducing-peptide) on disturbed human sleep.

Key finding

The study reports that sleep-promoting effects occurred only in the second hour after injection, in the first hour a slight arousing effect was indicated.

Experientia 1981

Direct Delta Sleep evidence. Relevant to Delta Sleep

PubMed
Review

Delta sleep-inducing peptide.

Key finding

This publication reports research findings relevant to delta sleep-inducing peptide.

European journal of anaesthesiology 2001

Direct Delta Sleep evidence. Relevant to Delta Sleep

PubMed
Human clinical

[Using deltalicin for the treatment of patients with diabetic retinopathy].

Key finding

The study reports that treatment with deltalicin (daily dose of 0.0003 g of delta sleep-inducing peptide intranasally for two months) decreased the latent period and led to less pronounced depression of VEP amplitude in patients with diabetic retinopathy, and reduced the period of restoration of VEP characteristics to.

Eksperimental'naia i klinicheskaia farmakologiia 2014

Research relevant to Delta Sleep. Relevant to Delta Sleep

PubMed
Human randomized

An RCT study on the feasibility of anterior transpedicular screw fixation in the cervicothoracic junction.

Key finding

The study reports that the transverse pedicle angle decreased from C6 (46.77° ± 2.72°) to T2 (20.62° ± 5.04°).

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 2016

Research relevant to Delta Sleep. Relevant to Delta Sleep

PubMed
Human clinical

Plasma concentration of nine hormones and neurotransmitters during usual activities or constant bed rest for 34 H.

Key finding

The study reports that compared with the "rest" condition, the "activity" condition increased heart rate, temperature, LH, and TSH in most subjects, and cortisol in two of five subjects.

Chronobiology international 1994

Research relevant to Delta Sleep. Relevant to Delta Sleep

PubMed
Human clinical

DSIP in insomnia.

Key finding

The study reports that a case of insomnia in organic brain disease responded well to higher doses.

European neurology 1984

Research relevant to Delta Sleep. Relevant to Delta Sleep

PubMed
Human clinical

A clinical trial with DSIP.

Key finding

The study reports that the mood and performance during the daytime improved as well.

European neurology 1984

Research relevant to Delta Sleep. Relevant to Delta Sleep

PubMed

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