Research across the Labbieux catalogue

Key finding

Daily eight-hour subcutaneous Kisspeptin-10 infusions maintained higher gonadotropin secretion across 12 days, while acute administration also increased LH, FSH, and testosterone in healthy men.

Key finding

This review describes anti-inflammatory, antioxidant, tissue-remodelling, wound-healing, and regenerative findings for GHK and GHK-Cu across laboratory and animal research.

Key finding

Intravenous Kisspeptin-10 produced a rapid, dose-dependent rise in LH. Continuous infusion also increased testosterone, LH pulse frequency, and pulse size in healthy men.

Key finding

The review links GHK and its copper complex with collagen and glycosaminoglycan regulation, fibroblast activity, tissue repair, and multiple skin-regeneration pathways.

Key finding

In men with low sexual desire, Kisspeptin-54 altered activity in sexual-processing brain networks and was associated with increased physiological arousal and several desire-related measures.

Key finding

This review brings together evidence on GHK-Cu and tissue repair, including dermal fibroblast function, collagen and elastin synthesis, inflammation, and gene-regulated protective pathways.

Key finding

At the tested intravenous doses, Kisspeptin-10 and Kisspeptin-54 generated broadly similar gonadotropin responses in healthy men, while GnRH produced the stronger response.

Key finding

In cultured human keratinocytes and skin-equivalent models, copper-free GHK increased cell proliferation, integrin expression, and markers associated with epidermal basal-cell stemness.

Key finding

In a small proof-of-concept study, Kisspeptin-10 increased LH secretion and pulse frequency in men with type 2 diabetes and mild biochemical hypogonadism, alongside higher testosterone.

Key finding

In normal and irradiated human dermal fibroblasts, GHK-Cu accelerated cell growth and increased early production of basic fibroblast growth factor and vascular endothelial growth factor.

Key finding

GHK, GGH, copper chloride, and their copper complexes decreased TNF-alpha-dependent IL-6 secretion in cultured normal human dermal fibroblasts.

Key finding

Intranasal Kisspeptin-54 rapidly increased LH in healthy men, healthy women, and women with hypothalamic amenorrhoea in a randomized crossover study.

Key finding

This review brings together evidence on GHK and GHK-Cu in tissue remodelling, including fibroblast and keratinocyte activity, growth-factor signalling, inflammation, wound repair, and changes observed in aged skin.

Key finding

In 95 participants, Kisspeptin-54 increased LH but did not significantly change measured anxiety, cortisol, blood pressure, or heart rate compared with placebo.

Key finding

In women with low sexual desire, Kisspeptin-54 modulated brain responses to sexual and attraction stimuli, with activity changes linked to lower aversion and baseline distress measures.

Key finding

Kisspeptin increased osteocalcin markers in 26 healthy men and, in laboratory models, promoted osteoblast differentiation while reducing osteoclast resorptive activity.

Key finding

Repeated Kisspeptin-54 administration stimulated reproductive hormones in a pilot group of women with PCOS; two of twelve participants developed a dominant follicle and ovulated.

Key finding

Kisspeptin altered resting-state connectivity in brain networks involved in sexual and emotional processing, with several connectivity changes correlating with psychometric responses.

Key finding

In healthy men, Kisspeptin increased limbic activity in response to sexual and couple-bonding stimuli, with responses linked to reward, drive, mood, and sexual-aversion measures.

Key finding

In five women with hypothalamic amenorrhoea, Kisspeptin-54 temporarily increased LH pulse frequency and pulse secretory mass, with the strongest dose differing by participant.