Research library

Key finding

In a phase I feasibility study and 28-person phase II randomized trial, UC-MSCs with hyaluronic acid were associated with earlier pain relief and functional improvement than bone-marrow aspirate concentrate with scaffold.

Key finding

In a 55-participant double-blind randomized trial, UC-MSC injection produced significant six-month improvements in pain, function and synovitis among participants with knee osteoarthritis and synovitis; no serious treatment-related adverse events were reported.

Key finding

A randomized, double-blind, placebo-controlled frailty study reported six-month improvements in physical quality-of-life scores, timed up-and-go and grip strength, with no difference in adverse-event incidence between groups.

Key finding

In a 91-person double-blind phase II trial, 20% of the UC-MSC group versus 4.55% of the placebo group met the combined 48-week HbA1c and insulin-reduction endpoint; no major transplantation-related adverse events were reported.

Key finding

In a 30-person phase I/II randomized heart-failure trial, the UC-MSC group showed improvements in left-ventricular ejection fraction, functional class and quality of life, with no infusion-related adverse events reported.

Key finding

Randomized human study examining Efficacy of a single dose of cryopreserved human umbilical cord mesenchymal stromal cells for the treatment of knee osteoarthritis:a randomized, controlled, double-blind pilot study.

Key finding

Randomized human study examining Predictive factors that influence the clinical efficacy of umbilical cord-derived mesenchymal stromal cells in the treatment of type 2 diabetes mellitus.

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Randomized human study examining Treatment of COVID-19-associated ARDS with umbilical cord-derived mesenchymal stromal cells in the STROMA-CoV-2 multicenter randomized double-blind trial: long-term safety, respiratory function, and quality of life.

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Randomized human study examining Efficacy and safety of human umbilical cord-derived mesenchymal stem cells versus placebo added to second-line therapy in patients with steroid-refractory acute graft-versus-host disease: a multicentre, randomized, double-blind, phase 2 trial.

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Randomized human study examining Effectiveness and safety of normoxic allogenic umbilical cord mesenchymal stem cells administered as adjunctive treatment in patients with severe COVID-19.

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Randomized human study examining Efficacy of Umbilical Cord-Derived Mesenchymal Stem Cells in the Treatment of Type 2 Diabetes Assessed by Retrospective Continuous Glucose Monitoring.

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Randomized human study examining Feasibility of reduced-dose posttransplant cyclophosphamide and cotransplantation of peripheral blood stem cells and umbilical cord-derived mesenchymal stem cells for SAA.

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Randomized human study examining Protective properties of heme oxygenase-1 expressed in umbilical cord mesenchymal stem cells help restore the ovarian function of premature ovarian failure mice through activating the JNK/Bcl-2 signal pathway-regulated autophagy and upregulating the circulating of CD8(+)CD28(-) T cells.

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Randomized human study examining Efficacy and safety of umbilical cord mesenchymal stem cells in treatment of cesarean section skin scars: a randomized clinical trial.

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Randomized human study examining Treatment of severe COVID-19 with human umbilical cord mesenchymal stem cells.

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Randomized human study examining The healing effect of Wharton's jelly stem cells seeded on biological scaffold in chronic skin ulcers: A randomized clinical trial.

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Randomized human study examining Umbilical Cord Mesenchymal Stem Cell Treatment for Crohn's Disease: A Randomized Controlled Clinical Trial.

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Randomized human study examining [The effect of liraglutide in combination with human umbilical cord mesenchymal stem cells treatment on glucose metabolism and β cell function in type 2 diabetes mellitus].

Key finding

Randomized human study examining Phase II Multicenter, Randomized, Double-Blind Controlled Study of Efficacy and Safety of Umbilical Cord-Derived Mesenchymal Stromal Cells in the Prophylaxis of Chronic Graft-Versus-Host Disease After HLA-Haploidentical Stem-Cell Transplantation.

Key finding

Randomized human study examining Effect of umbilical cord mesenchymal stromal cells on motor functions of identical twins with cerebral palsy: pilot study on the correlation of efficacy and hereditary factors.