Research library

Key finding

This review maps oxytocin signalling across social recognition, emotion, reward, memory, appetite, sleep, pain, sexual behaviour and autonomic regulation.

Key finding

The review links central oxytocin pathways to prosocial behaviour, bonding, care and cooperation while highlighting the context-dependent nature of these responses.

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A systematic review found that studies of oxytocin and human sexual behaviour used heterogeneous measures and produced context-dependent associations rather than one uniform systemic marker.

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In rhesus macaques, labelled intranasal oxytocin reached the orbitofrontal cortex, striatum, brainstem and thalamus, whereas labelled intravenous oxytocin was not detected in those regions.

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This systematic review of randomized trials found that intranasal oxytocin can alter anxiety- and depression-related outcomes, with effects varying by diagnosis, context and study design.

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The study reports that investigating intranasal oxytocin's efficacy, safety, and mechanisms as an anti-obesity medication will advance the search for optimal treatment strategies for obesity and its associated severe sequelae.

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The study reports that articles were selected that involved human participants with various psychiatric disorders and that either compared oxytocin biology to healthy controls or examined the effects of exogenous oxytocin administration.

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The study reports that many more shall be seen in the times to come.

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The study reports that notably, heightened oxytocin levels post-treatment were significantly associated with reduced OXTR DNA-methylation and improved feelings of secure attachment.

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The study reports that oxytocin led to a significant increase of 2.25 kg in whole body lean mass compared with placebo (P < .01) with a trend toward decreasing fat mass, and a significantly reduced plasma LDL cholesterol by -19.3 mg/dL (P = .023) compared against placebo.

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The study reports that the primary outcome will be compared between the two groups using a chi-square test with a p-value of 0.05.

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The study reports that intra-operative oxytocin infusion appears to be safe and effective in decreasing blood loss during abdominal myomectomy.

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The study reports that when pretreatment neuropeptide measures were included in the statistical model, OXT compared with placebo treatment significantly enhanced social abilities in children with ASD [as measured by the trial's primary outcome measure, the Social Responsiveness Scale (SRS)].

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The study reports that we observed a treatment effect on right amygdala activation during the processing of angry and happy face stimuli, with pairwise comparisons revealing reduced activation after the 8IU low dose intranasal treatment compared to placebo.

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The study reports that there were no significant differences between the women in the early and expectant oxytocin treatment groups in any of the four domains; however, operative births were associated with significantly worse childbirth experiences.

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Intranasal oxytocin has been shown to promote social functioning and has recently been applied as a treatment for autism spectrum disorders (ASD).

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Recent studies have suggested oxytocin as a possible drug to treat social deficits caused by autism spectrum disorder (ASD), but the safety of intranasal oxytocin in autistic patients has not been established.

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The study reports that here, we perform a Bayesian meta-analysis of the efficacy of IN-OT to improve areas of social and neurocognition in schizophrenia.

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The study reports that the use of oxytocin was associated with a reduction in the time to delivery of approximately two hours which might be important to some women.

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The study reports that oxytocin significantly reduced opioid-like withdrawal, anxiety symptoms, and cortisol levels elicited by cue exposure under noradrenergic activation produced by yohimbine.