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Research library

Explore selected publications, evidence types, key findings, and registered studies with direct links to each primary record. This curated library is not a complete archive of the thousands of studies across the wider scientific literature.

PublicationsClinical trials

5 publications

Showing records relevant to IGF-1 LR3.

Preclinical animal

Insulin-like growth factor-I (IGF-I) analogue, LR(3)IGF-I, ameliorates the loss of body weight but not of skeletal muscle during food restriction.

Key finding

The study reports that lR(3)IGF-I infusion increased fat loss only in young rats (P< 0.05) despite a reduction in plasma insulin levels in both age groups (P< 0.01).

Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society 2001

Research relevant to IGF-1 LR3. Relevant to IGF-1 LR3

PubMed
Published research

IGF-1 LR3 does not promote growth in late-gestation growth-restricted fetal sheep.

Key finding

The study reports that amino acid concentrations decreased in LR3 (baseline vs. final individual means comparison P = 0.0232) but not in VEH (P = 0.3866).

American journal of physiology. Endocrinology and metabolism 2025

Direct IGF-1 LR3 evidence. Relevant to IGF-1 LR3

PubMed
Review

Optimizing IGF-I for skeletal muscle therapeutics.

Key finding

The study reports that it is virtually undisputed that IGF-I promotes cell growth and survival.

Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society 2014

Research relevant to IGF-1 LR3. Relevant to IGF-1 LR3

PubMed
Preclinical animal

Revolutionary decellularized Alstroemeria stem-based nerve conduit integrated with GelMA and controlled IGF-1 LR3 release for enhanced rat sciatic nerve regeneration.

Key finding

The study reports that the IGF-1 LR3-controlled releasing decellularized conduit significantly improved axonal regeneration and showed comparable performance to autologous nerve grafts, without inducing systemic toxicity.

International journal of biological macromolecules 2025

Direct IGF-1 LR3 evidence. Relevant to IGF-1 LR3

PubMed
Preclinical animal

Intranasal long R3 insulin-like growth factor-1 treatment promotes amyloid plaque remodeling in cerebral cortex but fails to preserve cognitive function in male 5XFAD mice.

Key finding

The study reports that in male 5XFAD mice, IN LR3-IGF-1 treatment improved body composition, but did not significantly alter cognitive symptoms, as assessed by multiple assays.

Journal of Alzheimer's disease : JAD 2025

Research relevant to IGF-1 LR3. Relevant to IGF-1 LR3

PubMed

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