Research library
Explore selected publications, evidence types, key findings, and registered studies with direct links to each primary record. This curated library is not a complete archive of the thousands of studies across the wider scientific literature.
49 publications
Showing records relevant to GHRP-6.
The effects of GH-releasing peptide-6 (GHRP-6) and GHRP-2 on intracellular adenosine 3',5'-monophosphate (cAMP) levels and GH secretion in ovine and rat somatotrophs.
Key finding
The study reports that the cAMP antagonist did not prevent the effect of GHRP-6 on GH secretion whereas MDL 12,330A partially reduced the effect.
The Journal of endocrinology 1996
Direct GHRP-6 evidence. Relevant to GHRP-6
Epidermal growth factor and growth hormone-releasing peptide-6: combined therapeutic approach in experimental stroke.
Key finding
The study reports that eGF+GHRP6 co-administration reduced clinical manifestations and infarct volume and preserved neuronal density.
Restorative neurology and neuroscience 2013
Research relevant to GHRP-6. Relevant to GHRP-6
Adrenocorticotrophic hormone (ACTH) responsiveness to ghrelin increases after 6 months of ketoconazole use in patients with Cushing's disease: comparison with GH-releasing peptide-6 (GHRP-6).
Key finding
The study reports that gHRP-6-induced ACTH release also increased (before: 60.7 +/- 17.2; 6th month: 78.5 +/- 12.1), although not significantly.
Clinical endocrinology 2010
Direct GHRP-6 evidence. Relevant to GHRP-6
Effects of ghrelin, growth hormone-releasing peptide-6, and growth hormone-releasing hormone on growth hormone, adrenocorticotropic hormone, and cortisol release in type 1 diabetes mellitus.
Key finding
The study reports that chronic hyperglycemia of T1DM does not interfere with GH-, ACTH-, and cortisol-releasing mechanisms stimulated by these peptides.
Metabolism: clinical and experimental 2010
Research relevant to GHRP-6. Relevant to GHRP-6
Decreased ghrelin-induced GH release in thyrotoxicosis: comparison with GH-releasing peptide-6 (GHRP-6) and GHRH.
Key finding
The study reports that our data shows that GH release after ghrelin, GHRP-6 and GHRH administration is decreased in thyrotoxicosis.
Pituitary 2007
Direct GHRP-6 evidence. Relevant to GHRP-6
GHRP-6 is able to stimulate cortisol and ACTH release in patients with Cushing's disease: comparison with DDAVP.
Key finding
The study reports that there was a significant positive correlation between peak cortisol values after GHRP-6 and DDAVP administration (r = 0.87, p = 0.001).
Journal of endocrinological investigation 2003
Direct GHRP-6 evidence. Relevant to GHRP-6
Effects of ghrelin, GH-releasing peptide-6 (GHRP-6) and GHRH on GH, ACTH and cortisol release in hyperthyroidism before and after treatment.
Key finding
The study reports that after 3 months ACTH response to GHRP-6 decreased significantly (20.4 ± 4.2), with no further changes.
Pituitary 2010
Direct GHRP-6 evidence. Relevant to GHRP-6
Decreased GH secretion and enhanced ACTH and cortisol release after ghrelin administration in Cushing's disease: comparison with GH-releasing peptide-6 (GHRP-6) and GHRH.
Key finding
The study reports that in CD these responses (ghrelin: 192+/-43; GHRP-6: 185+/-56) were similar, and enhanced compared to controls.
Pituitary 2006
Direct GHRP-6 evidence. Relevant to GHRP-6
Growth hormone response to GHRH + GHRP-6 in type 2 diabetes during euglycemic and hyperglycemic clamp.
Key finding
The study reports that there was no difference in basal GH levels between the hyperglycemic and euglycemic clamps (2.9+/-0.99 mU/l versus 1.48+/-0.44 mU/l; P>0.05).
Diabetes research and clinical practice 2004
Direct GHRP-6 evidence. Relevant to GHRP-6
Arginine enhances the growth hormone-releasing activity of a synthetic hexapeptide (GHRP-6) in elderly but not in young subjects after oral administration.
Key finding
The study reports that on the other hand, it has been shown that arginine (ARG) totally restores the reduced somatotropic responsiveness to GHRH observed in aging.
Journal of endocrinological investigation 1994
Direct GHRP-6 evidence. Relevant to GHRP-6
Growth hormone responses to GH-releasing peptide (GHRP-6) in hypothyroidism.
Key finding
The study reports that when GHRP-6 was associated with GHRH, a significant increase in the GH response was observed in these patients, which could suggest a role for somatostatin in this process.
Clinical endocrinology 1997
Direct GHRP-6 evidence. Relevant to GHRP-6
Different effects of growth hormone releasing peptide (GHRP-6) and GH-releasing hormone on GH release in endogenous and exogenous hypercortisolism.
Key finding
The study reports that hypercortisolism had a different effect on the GH-releasing mechanisms stimulated by GHRH and GHRP-6.
Clinical endocrinology 1997
Direct GHRP-6 evidence. Relevant to GHRP-6
Growth hormone secretion after the administration of GHRP-6 or GHRH combined with GHRP-6 does not decline in late adulthood.
Key finding
The study reports that in contrast, GH responses to either GHRP-6 (F = 0.71, P = NS) or combined GHRH plus GHRP-6 administration (F = 0.68, P = NS) were not significantly different between the two groups.
Clinical endocrinology 1995
Direct GHRP-6 evidence. Relevant to GHRP-6
Pharmacokinetic study of Growth Hormone-Releasing Peptide 6 (GHRP-6) in nine male healthy volunteers.
Key finding
The study reports that gHRP-6 is a growth hormone secretagogue that also enhances tissue viability in different organs.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2013
Direct GHRP-6 evidence. Relevant to GHRP-6
Diagnosis of adrenal insufficiency using the GHRP-6 Test: comparison with the insulin tolerance test in patients with hypothalamic-pituitary-adrenal disease.
Key finding
The study reports that for GHRP6, the mean cortisol peak was 227+/-25.7 nmol/l in the AI group versus 395+/-35.3 nmol/l in the adrenal sufficient (AS) group.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 2010
Direct GHRP-6 evidence. Relevant to GHRP-6
Ghrelin and GHRP-6-induced ACTH and cortisol release in thyrotoxicosis.
Key finding
The study reports that delta AUC ACTH values after GHRP-6 were also higher, although not significantly (patients: 927 +/- 330; controls: 539 +/- 237).
Pituitary 2009
Direct GHRP-6 evidence. Relevant to GHRP-6
GH-releasing peptide (GHRP-6)-induced ACTH release in patients with addison's disease: effect of glucocorticoid withdrawal.
Key finding
The study reports that in control subjects, ACTH values (pmol/l; mean +/- SE) increased from 2.9 +/- 0.8 to 4.7 +/- 1.4 (peak).
Journal of endocrinological investigation 2003
Direct GHRP-6 evidence. Relevant to GHRP-6
Growth hormone-releasing effect of oral growth hormone-releasing peptide 6 (GHRP-6) administration in children with short stature.
Key finding
The study reports that the effect of oral GHRP-6 (300 micrograms/kg) was compared with that of the maximally effective dose of intravenous GH-releasing hormone (GHRH-29, 1 microgram/kg).
European journal of endocrinology 1995
Direct GHRP-6 evidence. Relevant to GHRP-6
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