Research library

Key finding

Targeting the blood vessels that support white adipose tissue caused selective vascular ablation and substantial fat loss in obese mice, establishing the core adipotide research strategy.

Key finding

Animal and cellular experiments identified endothelial prohibitin as a bidirectional transporter involved in long-chain fatty-acid movement into white and brown adipose tissue.

Key finding

The interaction between prohibitin and annexin A2 regulated fatty-acid transport across adipose vascular endothelium, clarifying a pathway used in adipose-targeting research.

Key finding

In-vivo phage display in people identified organ-specific vascular receptor signatures, providing the translational basis for selectively delivering compounds to defined tissues.

Key finding

Obesity, defined as body mass index greater than 30, is a leading cause of morbidity and mortality and a financial burden worldwide.

Key finding

Antiangiogenesis has been the focus of a new strategy for the treatment of obesity.

Key finding

These experiments provide compelling evidence for a previously unknown relationship between the status of adipose tissue vasculature and the regulation of food intake.

Key finding

Recent meta-analyses of new anti-obesity drugs and their weight-loss efficacy have shown that the overall placebo-subtracted weight reduction (%) for at least 12 months ranged from 2.9 to 6.8% for the following drugs: phentermine/topiramate (6.8%), liraglutide (5.4%), naltrexone/bupropion (4.0%), orlistat (2.9%), and lorcaserin (3.1%).

Key finding

A peptide designed to induce apoptosis of endothelium in white adipose tissue (WAT) decreases adiposity.

Key finding

We hypothesized that nonneoplastic tissue growth also depends on neovascularization.

Key finding

Prohibitins (PHBs) are scaffold proteins that modulate many signaling pathways controlling cell survival, metabolism, and inflammation.

Key finding

Development of obesity is characterized by hypertrophy and hyperplasia of adipocytes in white adipose tissue (WAT).

Key finding

The prohibitins, Phb1 and Phb2 are highly conserved proteins in eukaryotic cells that are present in multiple cellular compartments.

Key finding

The study reports that a study reporting that a peptidomimetic adipotide reduces weight loss in obese monkeys by inducing apoptosis of blood vessels surrounding white adipose tissue may instead reflect a direct effect of adipotide on food consumption.

Key finding

The study reports that the Mito-Ob mice develop obesity in a sex-neutral manner, but obesity-associated adipose inflammation and metabolic dysregulation in a male sex-specific manner.