Research library

Key finding

This publication examines [effect of the heptapeptide semax on the human electroencephalogram].

Key finding

Thus, we hypothesized and showed that one of Selank anti-anxiety molecular mechanisms can be associated with subtype selective concentration - dependent allosteric modulation of GABA receptors.

Key finding

Heptapeptide Semax (MEHFPGP) is the fragment of ACTH(4-10) analogue with prolonged neurotropic activity.

Key finding

Clinical studies have shown the similarity of the spectrum of physiological effects of Selank and classical benzodiazepines, such as diazepam and phenazepam.

Key finding

The heptapeptide Semax (Met-Glu-His-Phe-Pro-Gly-Pro) is an analog of the adrenocorticotropin fragment (4-10) which after intranasal application has profound effects on learning and exerts marked neuroprotective activities.

Key finding

The study reports that resting-state fMRI was carried out three times, namely before, after 5 and 20 min of the injection of either Semax, or Selank, or placebo.

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The study reports that at the same time, Selank decreased level of anxiety of rats with toxic damage of DA neurons in elevated cross shaped maze.

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The study reports that intranasal administration of Semax for 6 days decreased the volume of cortical infarction and improved retention and performance of conditioned passive avoidance response.

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The results extend therapeutic possibilities of treatment of anxietyspectrum disorders with the combination of benzodiazepine tranquilizers and selank.

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Sixty-two patients with generalized anxiety disorder (GAD) and neurasthenia were studied.

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Early rehabilitation and administration of semax increase BDNF plasma level, speed functional recovery, and improve motor performance.

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To study the efficacy and tolerability of the new anxyolytic peptide selank in comparison with phenazepam.

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Psychostimulants, such as methylphenidate, are currently the most common used drug therapy for children with attention-deficit hyperactivity disorder (ADHD).

Key finding

Activity of a peptide tuftsin analogue Selank was studied in outbred rats using the naloxone-precipitated morphine withdrawal model.

Key finding

The effects of a peptide anxiolytic Selank synthesized on the basis of the endogenous peptide tuftsin on memory impairment and content of brain-derived neurotrophic factor (BDNF) in brain structures were analyzed in outbred rats receiving 10% ethanol as the only source of fluid for 30 weeks.

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Brain stroke continues to claim the lives of million people every year.

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It was shown that the anxiolytic effect of Selank is comparable to that of classical benzodiazepine drugs and that the basis of their mechanism of action may be similar.

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This publication examines heptapeptide semax attenuates the effects of chronic unpredictable stress in rats.

Key finding

The effect of single and course administration of Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) in the dose 200 microg/kg on the rat hippocampus transcriptional profile were studied using cDNA microarray technology.

Key finding

This publication examines transcriptomic response of rat hippocampus and spleen cells to single and chronic administration of the peptide selank.