HGH

Evidence type

Human randomized study

Direct recombinant growth-hormone randomized evidence

Publication and key finding

Recombinant human growth hormone and rosiglitazone for abdominal fat accumulation in HIV-infected patients with insulin resistance: a randomized, double-blind, placebo-controlled, factorial trial.

In adults with HIV-associated abdominal obesity, rhGH reduced visceral fat by 22.7% over 12 weeks versus 1.9% in controls, while glucose measures worsened in the rhGH arm.

PloS one

Source

PMID 23593417 · 2013

Evidence type

Human randomized study

Direct growth-hormone fracture-healing trial

Publication and key finding

Effects of growth hormone in patients with tibial fracture: a randomised, double-blind, placebo-controlled clinical trial.

Growth hormone did not accelerate healing across all tibial fractures, but the prespecified closed-fracture subgroup healed in a median 95 days versus 129 days with placebo.

European journal of endocrinology

Source

PMID 17322494 · 2007

Evidence type

Human randomized study

Direct growth-hormone randomized clinical evidence

Publication and key finding

Growth hormone to improve short bowel syndrome intestinal autonomy: a pediatric randomized open-label clinical trial.

In children dependent on parenteral nutrition for short-bowel syndrome, growth hormone did not significantly improve weaning from parenteral nutrition compared with standard care.

JPEN. Journal of parenteral and enteral nutrition

Source

PMID 21975668 · 2011

Evidence type

Human randomized study

Direct long-term growth-hormone clinical evidence

Publication and key finding

Long-term efficacy and safety of two doses of growth hormone in short Japanese children born small for gestational age.

Five years of continuous growth-hormone treatment improved height standard-deviation scores in children born small for gestational age, with a larger response at the higher dose.

Hormone research in paediatrics

Source

PMID 22156542 · 2011