Humanin

Type bewijs

Observationele studie

Direct or closely related Humanin evidence

Publicatie en kernbevinding

Mechanisms of neuroprotection by a novel rescue factor humanin from Swedish mutant amyloid precursor protein.

We report a novel gene, designated Humanin (HN) cDNA, that suppresses neuronal cell death by K595N/M596L-APP (NL-APP), a mutant causing familial Alzheimer's disease (FAD), termed Swedish mutant.

Biochemical and biophysical research communications

Bron

PMID 11327724 · 2001

Type bewijs

Gepubliceerd onderzoek

Humanin mechanism or target context

Publicatie en kernbevinding

The role of mitochondrial derived peptides (MDPs) in metabolism.

This publication examines the role of mitochondrial derived peptides (mdps) in metabolism.

Journal of cellular physiology

Bron

PMID 25893266 · 2015

Type bewijs

Laboratoriumstudie

Direct or closely related Humanin evidence

Publicatie en kernbevinding

Naturally occurring mitochondrial-derived peptides are age-dependent regulators of apoptosis, insulin sensitivity, and inflammatory markers.

Mitochondria are key players in aging and in the pathogenesis of age-related diseases.

Aging

Bron

PMID 27070352 · 2016

Type bewijs

Preklinische studie

Direct or closely related Humanin evidence

Publicatie en kernbevinding

Humanin, a newly identified neuroprotective factor, uses the G protein-coupled formylpeptide receptor-like-1 as a functional receptor.

Alzheimer's disease (AD) is characterized by overproduction of beta amyloid peptides in the brain with progressive loss of neuronal cells.

Journal of immunology (Baltimore, Md. : 1950)

Bron

PMID 15153530 · 2004